HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis

HIF-1α, one of the most extensively studied oncogenes, is activated by a variety of microenvironmental factors. The resulting biological effects are thought to depend on its transcriptional activity. The RNAse enzyme Dicer is frequently downregulated in human cancers, which has been functionally lin...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Lai, Hui-Huang, Li, Jie-Ning, Wang, Ming-Yang, Huang, Hsin-Yi, Croce, Carlo M., Sun, Hui-Lung, Lyu, Yu-Jhen, Kang, Jui-Wen, Chiu, Ching-Feng, Hung, Mien-Chie, Suzuki, Hiroshi I., Chen, Pai-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785260/
https://ncbi.nlm.nih.gov/pubmed/29251629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89212
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