Cathepsin E Deficiency Impairs Autophagic Proteolysis in Macrophages

Cathepsin E is an endosomal aspartic proteinase that is predominantly expressed in immune-related cells. Recently, we showed that macrophages derived from cathepsin E-deficient (CatE (−/−)) mice display accumulation of lysosomal membrane proteins and abnormal membrane trafficking. In this study, we...

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Detalhes bibliográficos
Main Authors: Tsukuba, Takayuki, Yanagawa, Michiyo, Kadowaki, Tomoko, Takii, Ryosuke, Okamoto, Yoshiko, Sakai, Eiko, Okamoto, Kuniaki, Yamamoto, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855462/
https://ncbi.nlm.nih.gov/pubmed/24340026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082415
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