HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis

HIF-1α, one of the most extensively studied oncogenes, is activated by a variety of microenvironmental factors. The resulting biological effects are thought to depend on its transcriptional activity. The RNAse enzyme Dicer is frequently downregulated in human cancers, which has been functionally lin...

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Udgivet i:J Clin Invest
Main Authors: Lai, Hui-Huang, Li, Jie-Ning, Wang, Ming-Yang, Huang, Hsin-Yi, Croce, Carlo M., Sun, Hui-Lung, Lyu, Yu-Jhen, Kang, Jui-Wen, Chiu, Ching-Feng, Hung, Mien-Chie, Suzuki, Hiroshi I., Chen, Pai-Sheng
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785260/
https://ncbi.nlm.nih.gov/pubmed/29251629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89212
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