Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade–mediated tumor regression

Programmed death-1 receptor (PD-L1, B7-H1) and programmed cell death protein 1 (PD-1) pathway blockade is a promising therapy for treating cancer. However, the mechanistic contribution of host and tumor PD-L1 and PD-1 signaling to the therapeutic efficacy of PD-L1 and PD-1 blockade remains elusive....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Lin, Heng, Wei, Shuang, Hurt, Elaine M., Green, Michael D., Zhao, Lili, Vatan, Linda, Szeliga, Wojciech, Herbst, Ronald, Harms, Paul W., Fecher, Leslie A., Vats, Pankaj, Chinnaiyan, Arul M., Lao, Christopher D., Lawrence, Theodore S., Wicha, Max, Hamanishi, Junzo, Mandai, Masaki, Kryczek, Ilona, Zou, Weiping
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785251/
https://ncbi.nlm.nih.gov/pubmed/29337305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96113
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