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Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor
Live regulatory T cells (T(reg) cells) suppress antitumor immunity, but how T(reg) cells behave in the metabolically abnormal tumor microenvironment remains unknown. Here we show that tumor T(reg) cells undergo apoptosis, and such apoptotic T(reg) cells abolish spontaneous and PD-L1-blockade-mediate...
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| Pubblicato in: | Nat Immunol |
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| Autori principali: | , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5770150/ https://ncbi.nlm.nih.gov/pubmed/29083399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3868 |
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