Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor

Live regulatory T cells (T(reg) cells) suppress antitumor immunity, but how T(reg) cells behave in the metabolically abnormal tumor microenvironment remains unknown. Here we show that tumor T(reg) cells undergo apoptosis, and such apoptotic T(reg) cells abolish spontaneous and PD-L1-blockade-mediate...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Maj, Tomasz, Wang, Wei, Crespo, Joel, Zhang, Hongjuan, Wang, Weimin, Wei, Shuang, Zhao, Lili, Vatan, Linda, Shao, Irene, Szeliga, Wojciech, Lyssiotis, Costas, Liu, J Rebecca, Kryczek, Ilona, Zou, Weiping
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770150/
https://ncbi.nlm.nih.gov/pubmed/29083399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3868
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