Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor

Live regulatory T cells (T(reg) cells) suppress antitumor immunity, but how T(reg) cells behave in the metabolically abnormal tumor microenvironment remains unknown. Here we show that tumor T(reg) cells undergo apoptosis, and such apoptotic T(reg) cells abolish spontaneous and PD-L1-blockade-mediate...

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Udgivet i:Nat Immunol
Main Authors: Maj, Tomasz, Wang, Wei, Crespo, Joel, Zhang, Hongjuan, Wang, Weimin, Wei, Shuang, Zhao, Lili, Vatan, Linda, Shao, Irene, Szeliga, Wojciech, Lyssiotis, Costas, Liu, J Rebecca, Kryczek, Ilona, Zou, Weiping
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770150/
https://ncbi.nlm.nih.gov/pubmed/29083399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3868
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