Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Senescent cells (SnCs) accumulate in many vertebrate tissues with age and contribute to age-related pathologies(1–3), presumably through their secretion of factors contributing to the senescence-associated secretory phenotype (SASP)(4–6). Removal of SnCs delays several pathologies(7–9) and increases...

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Publicado no:Nat Med
Main Authors: Jeon, Ok Hee, Kim, Chaekyu, Laberge, Remi-Martin, Demaria, Marco, Rathod, Sona, Vasserot, Alain P, Chung, Jae Wook, Kim, Do Hun, Poon, Yan, David, Nathaniel, Baker, Darren J, van Deursen, Jan M, Campisi, Judith, Elisseeff, Jennifer H
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785239/
https://ncbi.nlm.nih.gov/pubmed/28436958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4324
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