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Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer
Fatty acid synthase (FASN) is a key lipogenic enzyme for de novo fatty acid biosynthesis and a druggable metabolic oncoprotein that is activated in most human cancers. We evaluated whether the HER2-driven lipogenic phenotype might represent a biomarker for sensitivity to pharmacological FASN blockad...
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| Publicat a: | Histol Histopathol |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5784426/ https://ncbi.nlm.nih.gov/pubmed/27714708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14670/HH-11-830 |
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