Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance

OBJECTIVE: Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD(+)), an essential co-substrate regulating a myriad of signaling pathways. We produced a mouse that overexpressed NAMPT in skeletal muscle...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Costford, Sheila R., Brouwers, Bram, Hopf, Meghan E., Sparks, Lauren M., Dispagna, Mauro, Gomes, Ana P., Cornnell, Heather H., Petucci, Chris, Phelan, Peter, Xie, Hui, Yi, Fanchao, Walter, Glenn A., Osborne, Timothy F., Sinclair, David A., Mynatt, Randall L., Ayala, Julio E., Gardell, Stephen J., Smith, Steven R.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784330/
https://ncbi.nlm.nih.gov/pubmed/29146412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.10.012
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