Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance

OBJECTIVE: Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD(+)), an essential co-substrate regulating a myriad of signaling pathways. We produced a mouse that overexpressed NAMPT in skeletal muscle...

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Bibliografische gegevens
Gepubliceerd in:Mol Metab
Hoofdauteurs: Costford, Sheila R., Brouwers, Bram, Hopf, Meghan E., Sparks, Lauren M., Dispagna, Mauro, Gomes, Ana P., Cornnell, Heather H., Petucci, Chris, Phelan, Peter, Xie, Hui, Yi, Fanchao, Walter, Glenn A., Osborne, Timothy F., Sinclair, David A., Mynatt, Randall L., Ayala, Julio E., Gardell, Stephen J., Smith, Steven R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2017
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784330/
https://ncbi.nlm.nih.gov/pubmed/29146412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.10.012
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