IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) is a life-threatening pathogen in humans. Bacterial infection of macrophages usually triggers strong innate immune mechanisms, including IL-1 cytokine secretion. The newer member of the IL-1 family, IL-36, was recently shown to be involved in cellular defense against...

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Udgivet i:Sci Rep
Main Authors: Ahsan, Fadhil, Maertzdorf, Jeroen, Guhlich-Bornhof, Ute, Kaufmann, Stefan H. E., Moura-Alves, Pedro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784124/
https://ncbi.nlm.nih.gov/pubmed/29367626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19476-x
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