Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice

The imidazole-based H3R antagonist 2-18 with high in vitro H3R antagonist affinity, excellent in vitro selectivity profile, and high in vivo H3R antagonist potency was tested for its anticonvulsant effect in maximal electroshock (MES)-induced convulsions in mice having valproic acid (VPA) as a refer...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Des Devel Ther
Hauptverfasser: Bastaki, Salim M, Abdulrazzaq, Yousef M, Shafiullah, Mohamed, Więcek, Małgorzata, Kieć-Kononowicz, Katarzyna, Sadek, Bassem
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2018
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5783147/
https://ncbi.nlm.nih.gov/pubmed/29403264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S144730
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