OS2.2 Paracrine impairment of antitumor T cell immunity by IDH1-mutant gliomas

BACKGROUND: The point mutation IDH1R132H is the most frequent one in grade II and grade III gliomas and secondary glioblastomas. We have previously shown that a peptide vaccine encoding the IDH1R132H epitope evokes an MHC II-restricted CD4+ T Helper-1 cell (Th1) immune response and is therapeutic in...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Bunse, L., Bunse, T., Pusch, S., Sahm, F., Sanghvi, K., Berghoff, A., Steadman, M., Niemeyer, B., Wick, W., Platten, M.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
OS2 Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5782512/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now188.012
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