OS1.4 Current treatment regimens induce the mTORC1 inhibitor REDD1 in human glioblastoma cells: implications for treatment efficacy

Glioblastoma is an incurable brain cancer with median survival of less than 1 year in unselected cohorts. Current treatment options include surgical resection and radiotherapy, alkylating chemotherapy with temozolomide or nitrosoureas. Hypoxia and nutrient depletion in the tumor microenvironment are...

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Udgivet i:Neuro Oncol
Main Authors: Foltyn, M., Thiepold, A., Harter, P. N., Baumgarten, P., Mittelbronn, M., Urban, H., Steinbach, J. P., Ronellenfitsch, M. W.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
OS1 Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5782506/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now188.006
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