P01.03 mTORC1 activation sensitizes human malignant glioma cells to hypoxia-induced cell death by increasing O2-consumption

Glioblastoma (GB) is an incurable brain cancer with median survival of less than one year in unselected cohorts. Current treatment of recurrent tumors frequently involves the VEGF-A-targeting antibody bevacizumab that causes local therapeutic hypoxia. After initial chemotherapy activating mutations...

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Bibliografske podrobnosti
izdano v:Neuro Oncol
Main Authors: Thiepold, A. L., Foltyn, M., Urban, H., Heller, S., Dröse, S., Harter, P. N., Mittelbronn, M., Steinbach, J. P., Ronellenfitsch, M. W.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
P01 Cell biology and signaling
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5782559/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now188.060
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