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Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites
Smc5/6, a member of the conserved SMC family of complexes, is essential for growth in most organisms. Its exact functions in a mitotic cell cycle are controversial, as chronic Smc5/6 loss-of-function alleles produce varying phenotypes. To circumvent this issue, we acutely depleted Smc5/6 in budding...
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| Veröffentlicht in: | PLoS Genet |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5779651/ https://ncbi.nlm.nih.gov/pubmed/29360860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007129 |
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