Acute Smc5/6 depletion reveals its primary role in rDNA replication by restraining recombination at fork pausing sites

Smc5/6, a member of the conserved SMC family of complexes, is essential for growth in most organisms. Its exact functions in a mitotic cell cycle are controversial, as chronic Smc5/6 loss-of-function alleles produce varying phenotypes. To circumvent this issue, we acutely depleted Smc5/6 in budding...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Peng, Xiao P., Lim, Shelly, Li, Shibai, Marjavaara, Lisette, Chabes, Andrei, Zhao, Xiaolan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779651/
https://ncbi.nlm.nih.gov/pubmed/29360860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007129
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