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Smc5/6 maintains stalled replication forks in a recombination-competent conformation

The Smc5/6 structural maintenance of chromosomes complex is required for efficient homologous recombination (HR). Defects in Smc5/6 result in chromosome mis-segregation and fragmentation. By characterising two Schizosaccharomyces pombe smc6 mutants, we define two separate functions for Smc5/6 in HR....

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Bibliographische Detailangaben
Hauptverfasser: Irmisch, Anja, Ampatzidou, Eleni, Mizuno, Ken'ichi, O'Connell, Matthew J, Murray, Johanne M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634738/
https://ncbi.nlm.nih.gov/pubmed/19158664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.273
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