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The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks
Mutations in SMARCAL1 (HARP) cause Schimke immunoosseous dysplasia (SIOD). The mechanistic basis for this disease is unknown. Using functional genomic screens, we identified SMARCAL1 as a genome maintenance protein. Silencing and overexpression of SMARCAL1 leads to activation of the DNA damage respo...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2764496/ https://ncbi.nlm.nih.gov/pubmed/19793861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1839909 |
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