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The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks
Mutations in SMARCAL1 (HARP) cause Schimke immunoosseous dysplasia (SIOD). The mechanistic basis for this disease is unknown. Using functional genomic screens, we identified SMARCAL1 as a genome maintenance protein. Silencing and overexpression of SMARCAL1 leads to activation of the DNA damage respo...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2764496/ https://ncbi.nlm.nih.gov/pubmed/19793861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1839909 |
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