The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks

Mutations in SMARCAL1 (HARP) cause Schimke immunoosseous dysplasia (SIOD). The mechanistic basis for this disease is unknown. Using functional genomic screens, we identified SMARCAL1 as a genome maintenance protein. Silencing and overexpression of SMARCAL1 leads to activation of the DNA damage respo...

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Bibliografiske detaljer
Main Authors: Bansbach, Carol E., Bétous, Rémy, Lovejoy, Courtney A., Glick, Gloria G., Cortez, David
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2009
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764496/
https://ncbi.nlm.nih.gov/pubmed/19793861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1839909
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