Modulating Cell-Surface Receptor Signaling and Ion Channel Functions by In Situ Glycan Editing

Glycans anchored on cell-surface receptors are active modulators of receptor signaling. A strategy is presented that enforces transient changes to cell-surface glycosylation patterns to tune receptor signaling. This approach, termed in situ glycan editing, exploits recombinant glycosyltransferases t...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Jiang, Hao, López-Aguilar, Aimé, Meng, Lu, Gao, Zhongwei, Liu, Yani, Tian, Xiao, Yu, Guangli, Ovryn, Ben, Moremen, Kelley W., Wu, Peng
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779621/
https://ncbi.nlm.nih.gov/pubmed/29292859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201706535
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