Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast

Aneuploidy and epigenetic alterations have long been associated with carcinogenesis, but it was unknown whether aneuploidy could disrupt the epigenetic states required for cellular differentiation. In this study, we found that ~3% of random aneuploid karyotypes in yeast disrupt the stable inheritanc...

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Опубликовано в: :eLife
Главные авторы: Mulla, Wahid A, Seidel, Chris W, Zhu, Jin, Tsai, Hung-Ji, Smith, Sarah E, Singh, Pushpendra, Bradford, William D, McCroskey, Scott, Nelliat, Anjali R, Conkright, Juliana, Peak, Allison, Malanowski, Kathryn E, Perera, Anoja G, Li, Rong
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2017
Предметы:
Cell Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779231/
https://ncbi.nlm.nih.gov/pubmed/28841138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27991
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