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Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast
Aneuploidy and epigenetic alterations have long been associated with carcinogenesis, but it was unknown whether aneuploidy could disrupt the epigenetic states required for cellular differentiation. In this study, we found that ~3% of random aneuploid karyotypes in yeast disrupt the stable inheritanc...
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| 發表在: | eLife |
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| Main Authors: | , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications, Ltd
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5779231/ https://ncbi.nlm.nih.gov/pubmed/28841138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27991 |
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