Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast

Aneuploidy and epigenetic alterations have long been associated with carcinogenesis, but it was unknown whether aneuploidy could disrupt the epigenetic states required for cellular differentiation. In this study, we found that ~3% of random aneuploid karyotypes in yeast disrupt the stable inheritanc...

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מידע ביבליוגרפי
הוצא לאור ב:eLife
Main Authors: Mulla, Wahid A, Seidel, Chris W, Zhu, Jin, Tsai, Hung-Ji, Smith, Sarah E, Singh, Pushpendra, Bradford, William D, McCroskey, Scott, Nelliat, Anjali R, Conkright, Juliana, Peak, Allison, Malanowski, Kathryn E, Perera, Anoja G, Li, Rong
פורמט: Artigo
שפה:Inglês
יצא לאור: eLife Sciences Publications, Ltd 2017
נושאים:
Cell Biology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779231/
https://ncbi.nlm.nih.gov/pubmed/28841138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27991
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