Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast

Aneuploidy and epigenetic alterations have long been associated with carcinogenesis, but it was unknown whether aneuploidy could disrupt the epigenetic states required for cellular differentiation. In this study, we found that ~3% of random aneuploid karyotypes in yeast disrupt the stable inheritanc...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Mulla, Wahid A, Seidel, Chris W, Zhu, Jin, Tsai, Hung-Ji, Smith, Sarah E, Singh, Pushpendra, Bradford, William D, McCroskey, Scott, Nelliat, Anjali R, Conkright, Juliana, Peak, Allison, Malanowski, Kathryn E, Perera, Anoja G, Li, Rong
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779231/
https://ncbi.nlm.nih.gov/pubmed/28841138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27991
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