Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair

The DNA damage response (DDR) is an extensive signaling network that is robustly mobilized by DNA double-strand breaks (DSBs). The primary transducer of the DSB response is the protein kinase, ataxia-telangiectasia, mutated (ATM). Here, we establish nuclear poly(A)-binding protein 1 (PABPN1) as a no...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Gavish-Izakson, Michal, Velpula, Bhagya Bhavana, Elkon, Ran, Prados-Carvajal, Rosario, Barnabas, Georgina D, Ugalde, Alejandro Pineiro, Agami, Reuven, Geiger, Tamar, Huertas, Pablo, Ziv, Yael, Shiloh, Yosef
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778506/
https://ncbi.nlm.nih.gov/pubmed/29253183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1240
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