Cargando...

Inactive Atm abrogates DSB repair in mouse cerebellum more than does Atm loss, without causing a neurological phenotype

The genome instability syndrome, ataxia-telangiectasia (A-T) is caused by null mutations in the ATM gene, that lead to complete loss or inactivation of the gene’s product, the ATM protein kinase. ATM is the primary mobilizer of the cellular response to DNA double-strand breaks (DSBs) – a broad signa...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:DNA Repair (Amst)
Main Authors: Tal, Efrat, Alfo, Marina, Zha, Shan, Barzilai, Ari, De Zeeuw, Chris I., Ziv, Yael, Shiloh, Yosef
Formato: Artigo
Idioma:Inglês
Publicado: 2018
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985968/
https://ncbi.nlm.nih.gov/pubmed/30348496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2018.10.001
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!