Inactive Atm abrogates DSB repair in mouse cerebellum more than does Atm loss, without causing a neurological phenotype

The genome instability syndrome, ataxia-telangiectasia (A-T) is caused by null mutations in the ATM gene, that lead to complete loss or inactivation of the gene’s product, the ATM protein kinase. ATM is the primary mobilizer of the cellular response to DNA double-strand breaks (DSBs) – a broad signa...

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發表在:DNA Repair (Amst)
Main Authors: Tal, Efrat, Alfo, Marina, Zha, Shan, Barzilai, Ari, De Zeeuw, Chris I., Ziv, Yael, Shiloh, Yosef
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985968/
https://ncbi.nlm.nih.gov/pubmed/30348496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2018.10.001
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