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Inactive Atm abrogates DSB repair in mouse cerebellum more than does Atm loss, without causing a neurological phenotype

The genome instability syndrome, ataxia-telangiectasia (A-T) is caused by null mutations in the ATM gene, that lead to complete loss or inactivation of the gene’s product, the ATM protein kinase. ATM is the primary mobilizer of the cellular response to DNA double-strand breaks (DSBs) – a broad signa...

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Detalhes bibliográficos
Publicado no:DNA Repair (Amst)
Main Authors: Tal, Efrat, Alfo, Marina, Zha, Shan, Barzilai, Ari, De Zeeuw, Chris I., Ziv, Yael, Shiloh, Yosef
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985968/
https://ncbi.nlm.nih.gov/pubmed/30348496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2018.10.001
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