Inactive Atm abrogates DSB repair in mouse cerebellum more than does Atm loss, without causing a neurological phenotype

The genome instability syndrome, ataxia-telangiectasia (A-T) is caused by null mutations in the ATM gene, that lead to complete loss or inactivation of the gene’s product, the ATM protein kinase. ATM is the primary mobilizer of the cellular response to DNA double-strand breaks (DSBs) – a broad signa...

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Bibliografske podrobnosti
izdano v:DNA Repair (Amst)
Main Authors: Tal, Efrat, Alfo, Marina, Zha, Shan, Barzilai, Ari, De Zeeuw, Chris I., Ziv, Yael, Shiloh, Yosef
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985968/
https://ncbi.nlm.nih.gov/pubmed/30348496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2018.10.001
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