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Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors
Influenza polymerase uses short capped primers snatched from nascent Pol II transcripts to initiate transcription of viral mRNAs. Here we describe crystal structures of influenza A and B polymerase bound to a capped primer in a configuration consistent with transcription initiation (’priming state’)...
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| Publicat a: | Nucleic Acids Res |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5778463/ https://ncbi.nlm.nih.gov/pubmed/29202182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1210 |
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