Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains

Influenza virus polymerase transcribes or replicates the segmented RNA genome (vRNA) into respectively viral mRNA or full-length copies and initiates RNA synthesis by binding the conserved 3′ and 5′ vRNA ends (the promoter). In recent structures of promoter-bound polymerase, the cap-binding and endo...

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Udgivet i:Mol Cell
Main Authors: Thierry, Eric, Guilligay, Delphine, Kosinski, Jan, Bock, Thomas, Gaudon, Stephanie, Round, Adam, Pflug, Alexander, Hengrung, Narin, El Omari, Kamel, Baudin, Florence, Hart, Darren J., Beck, Martin, Cusack, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712189/
https://ncbi.nlm.nih.gov/pubmed/26711008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.11.016
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