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Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer’s disease hallmarks
ADAM10 is a metalloproteinase acting on the amyloid precursor protein (APP) as an alpha-secretase in neurons. Its enzymatic activity results in secretion of a neuroprotective APP cleavage product (sAPP-alpha) and prevents formation of the amyloidogenic A-beta peptides, major hallmarks of Alzheimer’s...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5778060/ https://ncbi.nlm.nih.gov/pubmed/29358714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19577-7 |
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