Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer’s disease hallmarks

ADAM10 is a metalloproteinase acting on the amyloid precursor protein (APP) as an alpha-secretase in neurons. Its enzymatic activity results in secretion of a neuroprotective APP cleavage product (sAPP-alpha) and prevents formation of the amyloidogenic A-beta peptides, major hallmarks of Alzheimer’s...

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Foilsithe in:Sci Rep
Main Authors: Reinhardt, Sven, Stoye, Nicolai, Luderer, Mathias, Kiefer, Falk, Schmitt, Ulrich, Lieb, Klaus, Endres, Kristina
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778060/
https://ncbi.nlm.nih.gov/pubmed/29358714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19577-7
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