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Targeting BRCA1/2 deficient ovarian cancer with CNDAC-based drug combinations
PURPOSE: The mechanism of action of CNDAC (2′-C-cyano-2′-deoxy-1-β-d-arabino-pentofuranosyl-cytosine) is unique among deoxycytidine analogs because upon incorporation into DNA it causes a single strand break which is converted to a double strand break after DNA replication. This lesion requires homo...
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| Publicado no: | Cancer Chemother Pharmacol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5777892/ https://ncbi.nlm.nih.gov/pubmed/29189915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3483-6 |
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