TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors

2'-C-cyano-2'-deoxy-1-β-D-arabino-pentofuranosylcytosine (CNDAC) is the active metabolite of the anticancer drug, sapacitabine. CNDAC is incorporated into the genome during DNA replication and subsequently undergoes beta-elimination that generates single-strand breaks with abnormal 3’-ends...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Al Abo, Muthana, Sasanuma, Hiroyuki, Liu, Xiaojun, Rajapakse, Vinodh N, Huang, Shar-Yin, Kiselev, Evgeny, Takeda, Shunichi, Plunkett, William, Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971110/
https://ncbi.nlm.nih.gov/pubmed/28802254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0110
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