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CNDAC-induced DNA double strand breaks cause aberrant mitosis prior to cell death
Incorporation of the clinically active deoxycytidine analog, 2’-C-cyano-2’-deoxy-1-β-D-arabino-pentofuranosyl-cytosine (CNDAC) into DNA generates single strand breaks that are subsequently converted to double strand breaks (DSBs). Here, we investigated the cellular manifestations of these breaks tha...
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| Publicado no: | Mol Cancer Ther |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7433019/ https://ncbi.nlm.nih.gov/pubmed/31501277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1380 |
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