Oncogenic dependency on β-catenin in liver cancer cell lines correlates with pathway activation

Hepatocellular carcinoma (HCC) represents a serious public health challenge with few therapeutic options available to cancer patients.Wnt/β-catenin pathway is thought to play a significant role in HCC pathogenesis. In this study, we confirmed high frequency of CTNNB1 (β-catenin) mutations in two ind...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Ding, Zhihu, Shi, Chaomei, Jiang, Lan, Tolstykh, Tatiana, Cao, Hui, Bangari, Dinesh S., Ryan, Susan, Levit, Mikhail, Jin, Taiguang, Mamaat, Karl, Yu, Qunyan, Qu, Hui, Hopke, Joern, Cindhuchao, May, Hoffmann, Dietmar, Sun, Fangxian, Helms, Mike W., Jahn-Hofmann, Kerstin, Scheidler, Sabine, Schweizer, Liang, Fang, Douglas D., Pollard, Jack, Winter, Christopher, Wiederschain, Dmitri
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777711/
https://ncbi.nlm.nih.gov/pubmed/29383099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21298
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