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1α,25-Dihydroxyvitamin D Inhibits de novo Fatty Acid Synthesis and Lipid Accumulation in Metastatic Breast Cancer Cells through Downregulation of Pyruvate Carboxylase

Both increased de novo fatty acid synthesis and higher neutral lipid accumulation are a common phenotype observed in aggressive breast cancer cells, making lipid metabolism a promising target for breast cancer prevention. In the present studies we demonstrate a novel effect of the active metabolite...

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Detalles Bibliográficos
Publicado en:J Nutr Biochem
Autores principales: Wilmanski, Tomasz, Buhman, Kimberly, Donkin, Shawn S., Burgess, John R., Teegarden, Dorothy
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777513/
https://ncbi.nlm.nih.gov/pubmed/27936456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jnutbio.2016.11.006
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