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1α,25-Dihydroxyvitamin D Inhibits de novo Fatty Acid Synthesis and Lipid Accumulation in Metastatic Breast Cancer Cells through Downregulation of Pyruvate Carboxylase

Both increased de novo fatty acid synthesis and higher neutral lipid accumulation are a common phenotype observed in aggressive breast cancer cells, making lipid metabolism a promising target for breast cancer prevention. In the present studies we demonstrate a novel effect of the active metabolite...

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Bibliografske podrobnosti
izdano v:J Nutr Biochem
Main Authors: Wilmanski, Tomasz, Buhman, Kimberly, Donkin, Shawn S., Burgess, John R., Teegarden, Dorothy
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777513/
https://ncbi.nlm.nih.gov/pubmed/27936456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jnutbio.2016.11.006
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