Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma

BACKGROUND: Combined immunotherapy approaches are promising cancer treatments. We evaluated anti–programmed cell death protein 1 (PD-1) treatment combined with gene-mediated cytotoxic immunotherapy (GMCI) performed by intratumoral injection of a prodrug metabolizing nonreplicating adenovirus (AdV-tk...

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Vydáno v:Neuro Oncol
Hlavní autoři: Speranza, Maria-Carmela, Passaro, Carmela, Ricklefs, Franz, Kasai, Kazue, Klein, Sarah R, Nakashima, Hiroshi, Kaufmann, Johanna K, Ahmed, Abdul-Kareem, Nowicki, Michal O, Obi, Prisca, Bronisz, Agnieszka, Aguilar-Cordova, Estuardo, Aguilar, Laura K, Guzik, Brian W, Breakefield, Xandra, Weissleder, Ralph, Freeman, Gordon J, Reardon, David A, Wen, Patrick Y, Chiocca, E Antonio, Lawler, Sean E
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777502/
https://ncbi.nlm.nih.gov/pubmed/29016938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox139
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