Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene

rQNestin34.5v.2 is an oncolytic herpes simplex virus 1 (oHSV) that retains expression of the neurovirulent ICP34.5 gene under glioma-selective transcriptional regulation. To prepare an investigational new drug (IND) application, we performed toxicology and efficacy studies of rQNestin34.5v.2 in mice...

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Vydáno v:Mol Ther Methods Clin Dev
Hlavní autoři: Chiocca, E. Antonio, Nakashima, Hiroshi, Kasai, Kazue, Fernandez, Soledad A., Oglesbee, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195500/
https://ncbi.nlm.nih.gov/pubmed/32373649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.03.028
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