Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents

Genomic instability plays a pathological role in various malignancies, including acute myeloid leukemia (AML), and thus represents a potential therapeutic target. Recent studies demonstrate that SIRT6, a NAD(+)-dependent nuclear deacetylase, functions as genome-guardian by preserving DNA integrity i...

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Publicat a:Haematologica
Autors principals: Cagnetta, Antonia, Soncini, Debora, Orecchioni, Stefania, Talarico, Giovanna, Minetto, Paola, Guolo, Fabio, Retali, Veronica, Colombo, Nicoletta, Carminati, Enrico, Clavio, Marino, Miglino, Maurizio, Bergamaschi, Micaela, Nahimana, Aimable, Duchosal, Michel, Todoerti, Katia, Neri, Antonino, Passalacqua, Mario, Bruzzone, Santina, Nencioni, Alessio, Bertolini, Francesco, Gobbi, Marco, Lemoli, Roberto M., Cea, Michele
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777193/
https://ncbi.nlm.nih.gov/pubmed/29025907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.176248
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