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FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes

FoxP3(+) regulatory T cells (Tregs) are a central element of immunological tolerance. FoxP3 is the key determining transcription factor of the Treg lineage, interacting with numerous cofactors and transcriptional targets to determine the many facets of Treg function. Its absence leads to devastating...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Kwon, Ho-Keun, Chen, Hui-Min, Mathis, Diane, Benoist, Christophe
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777076/
https://ncbi.nlm.nih.gov/pubmed/29269391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718599115
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