Structural basis of the phosphorylation-independent recognition of cyclin D1 by the SCF(FBXO31) ubiquitin ligase

Ubiquitin-dependent proteolysis of cyclin D1 is associated with normal and tumor cell proliferation and survival. The SCF(FBXO31) (Skp1–Cul1–Rbx1–FBXO31) ubiquitin ligase complex mediates genotoxic stress-induced cyclin D1 degradation. Previous studies have suggested that cyclin D1 levels are mainta...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Li, Yunfeng, Jin, Kai, Bunker, Eric, Zhang, Xiaojuan, Luo, Xuemei, Liu, Xuedong, Hao, Bing
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777030/
https://ncbi.nlm.nih.gov/pubmed/29279382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708677115
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