Estrogen-dependent epigenetic regulation of soluble epoxide hydrolase via DNA methylation

To elucidate molecular mechanisms responsible for the sexually dimorphic phenotype of soluble epoxide hydrolase (sEH) expression, we tested the hypothesis that female-specific down-regulation of sEH expression is driven by estrogen-dependent methylation of the Ephx2 gene. Mesenteric arteries isolate...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Yang, Yang-Ming, Sun, Dong, Kandhi, Sharath, Froogh, Ghezal, Zhuge, Jian, Huang, Weihua, Hammock, Bruce D., Huang, An
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776989/
https://ncbi.nlm.nih.gov/pubmed/29295935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716016115
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