Estrogen-dependent epigenetic regulation of soluble epoxide hydrolase via DNA methylation

To elucidate molecular mechanisms responsible for the sexually dimorphic phenotype of soluble epoxide hydrolase (sEH) expression, we tested the hypothesis that female-specific down-regulation of sEH expression is driven by estrogen-dependent methylation of the Ephx2 gene. Mesenteric arteries isolate...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Yang, Yang-Ming, Sun, Dong, Kandhi, Sharath, Froogh, Ghezal, Zhuge, Jian, Huang, Weihua, Hammock, Bruce D., Huang, An
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776989/
https://ncbi.nlm.nih.gov/pubmed/29295935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716016115
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