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Dissecting the genetic and metabolic mechanisms of adaptation to the knockout of a major metabolic enzyme in Escherichia coli

Unraveling the mechanisms of microbial adaptive evolution following genetic or environmental challenges is of fundamental interest in biological science and engineering. When the challenge is the loss of a metabolic enzyme, adaptive responses can also shed significant insight into metabolic robustne...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Long, Christopher P., Gonzalez, Jacqueline E., Feist, Adam M., Palsson, Bernhard O., Antoniewicz, Maciek R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776819/
https://ncbi.nlm.nih.gov/pubmed/29255023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716056115
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