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Dissecting the genetic and metabolic mechanisms of adaptation to the knockout of a major metabolic enzyme in Escherichia coli

Unraveling the mechanisms of microbial adaptive evolution following genetic or environmental challenges is of fundamental interest in biological science and engineering. When the challenge is the loss of a metabolic enzyme, adaptive responses can also shed significant insight into metabolic robustne...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Long, Christopher P., Gonzalez, Jacqueline E., Feist, Adam M., Palsson, Bernhard O., Antoniewicz, Maciek R.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776819/
https://ncbi.nlm.nih.gov/pubmed/29255023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716056115
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