Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action

Protein–protein interactions are essential for the control of cellular functions and are critical for regulation of the immune system. One example is the binding of Fc regions of IgG to the Fc gamma receptors (FcγRs). High sequence identity (98%) between the genes encoding FcγRIIIa (expressed on mac...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Robinson, James I., Baxter, Euan W., Owen, Robin L., Thomsen, Maren, Tomlinson, Darren C., Waterhouse, Mark P., Win, Stephanie J., Nettleship, Joanne E., Tiede, Christian, Foster, Richard J., Owens, Raymond J., Fishwick, Colin W. G., Harris, Sarah A., Goldman, Adrian, McPherson, Michael J., Morgan, Ann W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776790/
https://ncbi.nlm.nih.gov/pubmed/29247053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707856115
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