Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action

Protein–protein interactions are essential for the control of cellular functions and are critical for regulation of the immune system. One example is the binding of Fc regions of IgG to the Fc gamma receptors (FcγRs). High sequence identity (98%) between the genes encoding FcγRIIIa (expressed on mac...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Robinson, James I., Baxter, Euan W., Owen, Robin L., Thomsen, Maren, Tomlinson, Darren C., Waterhouse, Mark P., Win, Stephanie J., Nettleship, Joanne E., Tiede, Christian, Foster, Richard J., Owens, Raymond J., Fishwick, Colin W. G., Harris, Sarah A., Goldman, Adrian, McPherson, Michael J., Morgan, Ann W.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776790/
https://ncbi.nlm.nih.gov/pubmed/29247053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707856115
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