Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action

Protein–protein interactions are essential for the control of cellular functions and are critical for regulation of the immune system. One example is the binding of Fc regions of IgG to the Fc gamma receptors (FcγRs). High sequence identity (98%) between the genes encoding FcγRIIIa (expressed on mac...

詳細記述

保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Robinson, James I., Baxter, Euan W., Owen, Robin L., Thomsen, Maren, Tomlinson, Darren C., Waterhouse, Mark P., Win, Stephanie J., Nettleship, Joanne E., Tiede, Christian, Foster, Richard J., Owens, Raymond J., Fishwick, Colin W. G., Harris, Sarah A., Goldman, Adrian, McPherson, Michael J., Morgan, Ann W.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2018
主題:
PNAS Plus
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776790/
https://ncbi.nlm.nih.gov/pubmed/29247053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707856115
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