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Discovery of novel N-aryl piperazine CXCR4 antagonists
A novel series of CXCR4 antagonists with substituted piperazines as benzimidazole replacements is described. These compounds showed micromolar to nanomolar potency in CXCR4-mediated functional and HIV assays, namely inhibition of X4 HIV-1(IIIB) virus in MAGI-CCR5/CXCR4 cells and inhibition of SDF-1...
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| Publicat a: | Bioorg Med Chem Lett |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5776727/ https://ncbi.nlm.nih.gov/pubmed/25935642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.04.036 |
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