Calcitriol-mediated reduction in IFN-γ output in T cell large granular lymphocytic leukemia requires vitamin D receptor upregulation

Constitutively activated STAT1 and elevated IFN-γ are both characteristic of T cell large granular lymphocytic leukemia (T-LGLL), a rare incurable leukemia with clonal expansion of cytotoxic T cells due to defective apoptosis. Interferon gamma (IFN-γ) is an inflammatory cytokine that correlates with...

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Pubblicato in:J Steroid Biochem Mol Biol
Autori principali: Kulling, Paige M, Olson, Kristine C, Olson, Thomas L, Hamele, Cait E, Carter, Kathryn N, Feith, David J, Loughran, Thomas P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775933/
https://ncbi.nlm.nih.gov/pubmed/28736298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2017.07.009
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