The CXCR4–STAT3–IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide

Chronic lymphocytic leukemia (CLL) cells possess regulatory functions comparable to those of normal B10 cells, a regulatory B cell subset that suppresses effector T-cell function through STAT3-mediated IL-10 production. However, the mechanisms governing IL-10 production by CLL cells are not fully un...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Shaim, Hila, Estrov, Zeev, Harris, David, Hernandez Sanabria, Mayra, Liu, Zhiming, Ruvolo, Peter, Thompson, Phillip A., Ferrajoli, Alessandra, Daher, May, Burger, Jan, Muftuoglu, Muharrem, Imahashi, Nobuhiko, Li, Li, Liu, Enli, Alsuliman, Abdullah Saleh, Basar, Rafet, Nassif Kerbauy, Lucila, Sobieski, Catherine, Gokdemir, Elif, Kondo, Kayo, Wierda, William, Keating, Michael, Shpall, Elizabeth J., Rezvani, Katayoun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775272/
https://ncbi.nlm.nih.gov/pubmed/29379494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01773
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