The CXCR4–STAT3–IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide

Chronic lymphocytic leukemia (CLL) cells possess regulatory functions comparable to those of normal B10 cells, a regulatory B cell subset that suppresses effector T-cell function through STAT3-mediated IL-10 production. However, the mechanisms governing IL-10 production by CLL cells are not fully un...

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Vydáno v:Front Immunol
Hlavní autoři: Shaim, Hila, Estrov, Zeev, Harris, David, Hernandez Sanabria, Mayra, Liu, Zhiming, Ruvolo, Peter, Thompson, Phillip A., Ferrajoli, Alessandra, Daher, May, Burger, Jan, Muftuoglu, Muharrem, Imahashi, Nobuhiko, Li, Li, Liu, Enli, Alsuliman, Abdullah Saleh, Basar, Rafet, Nassif Kerbauy, Lucila, Sobieski, Catherine, Gokdemir, Elif, Kondo, Kayo, Wierda, William, Keating, Michael, Shpall, Elizabeth J., Rezvani, Katayoun
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775272/
https://ncbi.nlm.nih.gov/pubmed/29379494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01773
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