The CXCR4–STAT3–IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide

Chronic lymphocytic leukemia (CLL) cells possess regulatory functions comparable to those of normal B10 cells, a regulatory B cell subset that suppresses effector T-cell function through STAT3-mediated IL-10 production. However, the mechanisms governing IL-10 production by CLL cells are not fully un...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Shaim, Hila, Estrov, Zeev, Harris, David, Hernandez Sanabria, Mayra, Liu, Zhiming, Ruvolo, Peter, Thompson, Phillip A., Ferrajoli, Alessandra, Daher, May, Burger, Jan, Muftuoglu, Muharrem, Imahashi, Nobuhiko, Li, Li, Liu, Enli, Alsuliman, Abdullah Saleh, Basar, Rafet, Nassif Kerbauy, Lucila, Sobieski, Catherine, Gokdemir, Elif, Kondo, Kayo, Wierda, William, Keating, Michael, Shpall, Elizabeth J., Rezvani, Katayoun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775272/
https://ncbi.nlm.nih.gov/pubmed/29379494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01773
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