CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells

Adoptive transfer of T cells genetically modified to express a cancer-specific T-cell receptor (TCR) has shown significant therapeutic potential for both hematological and solid tumors. However, a major issue of transducing T cells with a transgenic TCR is the preexisting expression of TCRs in the r...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Legut, Mateusz, Dolton, Garry, Mian, Afsar Ali, Ottmann, Oliver G., Sewell, Andrew K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2018
Fag:
Gene Therapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5774207/
https://ncbi.nlm.nih.gov/pubmed/29122757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-787598
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